Homo sapiens Exome

This was a retrospective study in which WES was performed on OCT-embedded tumor tissue and paired adjacent normal tissue from 12 patients diagnosed with incident SNSCC at the University of Cincinnati Cancer Center from 2012 to 2014. We identified 263 genes that harbored two or more coding region somatic mutations in multiple SNSCC tumors. Eight genes were significantly mutated (q < 0.1). This study helps elucidate the mutational landscape of SNSCC, advancing our understanding of its genesis and yielding potential new therapeutic avenues for management of this uncommon, though important, malignancy.