Cis-regulatory architecture of human ESC-derived hypothalamic neuron differentiation aids in variant-to-gene mapping of relevant common complex traits (Capture C)

To investigate the role of the hypothalamus in complex traits, we generated ATAC-seq, RNA-seq, and Promoter Focused Capture C to gain insight into the gene regulatory arcitecture contacting promoters in an embryonic stem cell dervived model of hypothalamic neuron differentiation We performed ATAC-seq, RNA-seq, and Promoter Focused Capture C on stages of ESC dervived hypothalamic like neuron differentiation (ESC: day 0; HP: day 12; HN: day 27).