Table 5 in Chemical constituents derived from Artocarpus xanthocarpus as inhibitors of melanin biosynthesis

Table 5 Effect of selected compounds on melanin content, tyrosinase activity, and cell viability in B16F10 melanoma cells.
CompoundsCon. (µµ)Cell viability (% of control)aMelanin content (% of control)bTyrosinase activity (% of control)bControl100.0 ± 1.7100.0 ± 2.5100.0 ± 1.2OE- MSHnd121.1 ± 11.5 #120.5 ± 4.3 #1210101.0 ± 1.7105.7 ± 2.3 ⁄137.2 ± 6.1 ⁄161093.9 ± 9.5101.0 ± 8.0 ⁄117.8 ± 8.51710107.0 ± 11.076.3 ± 2.9 ⁄75.2 ± 8.8 ⁄181099.7 ± 1.970.8 ± 1.5 ⁄88.7 ± 10.1 ⁄194099.7 ± 1.992.0 ± 15.2 ⁄89.2 ± 6.8 ⁄204099.7 ± 9.4107.4 ± 10.7127.6 ± 3.6214095.2 ± 3.458.0 ± 2.2 ⁄69.2 ± 4.0⁄
Nd: not determined. Data represents the mean ± S.D. (n = 3–6). (#) <0.05 indicates significant differences from the control group. (⁄) <0.05, ** p <0.01 indicates significant differences from the OE- MSH treated group.
a Effect of compounds on cell viability of B16F10 melanoma cells.
b The inhibitory effect on melanin production and tyrosinase activity in B16F10 melanoma cells stimulated by 50 nM OE- MSH.