Multifunctional dynamic hydrogels crosslinked with boronic ester and disulfide bonds reinforced with oxidized cellulose nanofibers for self-healing, motion sensing, and controlled drug release

This study presents a novel multifunctional dynamic hydrogel, cross-linked with boronic ester and disulfide bonds, and incorporating oxidized bacterial cellulose nanofibers (OBCNF). The OBCNF content was optimized to achieve a material with optimal mechanical properties. The presence of dynamic boronic ester and disulfide bonds enabled efficient self-healing behavior. Moreover, the hydrogel proved to be highly effective as a flexible sensor for monitoring motion. It demonstrated stable changes in conductivity under mechanical deformation, making it suitable for applications in wearable electronics. The hydrogel also exhibited specific degradation behavior in acidic and oxidative environments, where disulfide bonds and boronic ester linkages were selectively cleaved, leading to controlled degradation of the material. Additionally, the hydrogels were shown to be cytocompatible and enable pH-dependent release of incorporated doxorubicin (DOX), with significantly higher release rates observed at lower pH, with an increase of total amount of DOX release from ~20% to ~70% when decreasing the pH from 7.4 to 5.1. These properties make the hydrogel promising from the point of view of biomedical applications. Altogether, we introduced a dynamic hydrogel based on dual dynamic covalent bond crosslinking as promising approach for development of multifaceted smart materials.

本研究报道了一种新型多功能动态水凝胶，该水凝胶通过硼酸酯键与二硫键进行交联，并引入了氧化细菌纤维素纳米纤维（oxidized bacterial cellulose nanofibers, OBCNF）。研究对OBCNF的含量进行了优化，以获得力学性能最优的该类材料。动态硼酸酯与二硫键的存在赋予其高效的自修复性能。此外，该水凝胶作为柔性传感器可有效实现运动监测：其在机械形变下电导率变化稳定，适用于可穿戴电子器件应用场景。该水凝胶在酸性与氧化环境中表现出特异性降解行为：二硫键与硼酸酯键会被选择性断裂，从而实现材料的可控降解。此外，该水凝胶具备细胞相容性，可实现负载的阿霉素（doxorubicin, DOX）的pH响应型释放；当pH从7.4降至5.1时，阿霉素总释放量从约20%提升至约70%，低pH条件下释放速率显著更高。上述特性使得该水凝胶在生物医学领域具备良好的应用前景。综上，本研究提出了一种基于双重动态共价键交联的动态水凝胶，为多功能智能材料的开发提供了极具潜力的技术路径。

搜集汇总

背景与挑战

背景概述

该数据集介绍了一种基于硼酸酯和二硫键双重动态共价交联、并采用氧化细菌纤维素纳米纤维增强的多功能动态水凝胶。该水凝胶具有自修复能力、可作为柔性运动传感器，并表现出pH依赖性的药物释放特性，适用于生物医学和可穿戴电子等领域。