MRM profiiling dataset - Milk and mammary gland Scd1 global knockout (GKO) and WT C57BL/6 mice

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<p>This dataset was acuquired to study the effect of <em>Scd1</em> deficiency on the mammary gland and milk lipid profile during lactation, a period characterized by intense mammary lipogenic activity, and its subsequent effect on neonatal weight.</p>

<p>In this study, we utilized wild-type (WT; n=7) and <em>Scd1</em>-/- (<em>Scd1</em> global knockout (GKO)) (n=6) mice and bred them twice. Thus, all studies were conducted on second parity dams, so all growth data for neonates, milk, and mammary are from second parity dams. Mice were initially paired at ~7 weeks of age, permitting a complete reproductive cycle and allowing dams to nurse their pups. After weaning, mice were re-paired to generate a second litter. To ensure that all pups were of the same genotype, GKO females were mated with WT males, while WT females were bred with GKO males, resulting in heterozygous offspring. Pregnancy was closely monitored, and litters were standardized to 5 pups per dam on postnatal day 2, with surplus pups cross-fostered to other mice within the colony. All mice nursed their 5 pups until day 10 of lactation, except one GKO female, which had three pups whose weight was within the range of pups from other GKO dams.</p>
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