RSNA-ASNR-MICCAI-BraTS-2021

This dataset includes brain MRI scans of adult brain glioma patients, comprising of 4 structural modalities (i.e., T1, T1c, T2, T2-FLAIR) and associated manually generated ground truth labels for each tumor sub-region (enhancement, necrosis, edema), as well as their MGMT promoter methylation status. These scans are a collection of data from existing TCIA collections, but also cases provided by individual institutions and willing to share with a cc-by license. The BraTS dataset describes a retrospective collection of brain tumor structural mpMRI scans of 2,040 patients, acquired from multiple different institutions under standard clinical conditions, but with different equipment and imaging protocols, resulting in a vastly heterogeneous image quality reflecting diverse clinical practice across different institutions. The 4 structural mpMRI scans included in the BraTS challenge describe a) native (T1) and b) post-contrast T1-weighted (T1Gd (Gadolinium)), c) T2-weighted (T2), and d) T2 Fluid Attenuated Inversion Recovery (T2-FLAIR) volumes, acquired with different protocols and various scanners from multiple institutions. Furthermore, data on the O[6]-methylguanine-DNA methyltransferase (MGMT) promoter methylation status is provided as a binary label. Notably, MGMT is a DNA repair enzyme that the methylation of its promoter in newly diagnosed glioblastoma has been identified as a favorable prognostic factor and a predictor of chemotherapy response. It is curated for computational image analysis of segmentation and prediction of the MGMT promoter methylation status.

本数据集涵盖成人脑胶质瘤患者的脑部磁共振成像（MRI）扫描数据，包含4种结构模态（即T1、T1c、T2、T2-FLAIR），以及针对各肿瘤亚区域（增强区域、坏死区域、水肿区域）的人工金标准标注（ground truth），同时附带患者的O6-甲基鸟嘌呤-DNA甲基转移酶（MGMT）启动子甲基化状态信息。该扫描数据既整合了现有癌症影像档案库（TCIA）中的数据集，也包含来自自愿遵循知识共享署名（CC BY）许可共享数据的各医疗机构提供的病例数据。

脑肿瘤分割挑战赛（BraTS）数据集为回顾性汇编数据集，涵盖2040名患者的脑部肿瘤结构型多参数磁共振成像（mpMRI）扫描数据。该数据由多家不同机构在标准临床流程下采集，但使用了各异的成像设备与扫描协议，因此图像质量存在显著异质性，充分反映了不同医疗机构间多样化的临床实践模式。

本次BraTS挑战赛所用的4种结构模态mpMRI扫描分别为：a) 平扫T1成像容积（T1）、b) 钆剂增强T1加权成像容积（T1Gd，钆（Gadolinium））、c) T2加权成像容积（T2）以及d) T2液体衰减反转恢复成像容积（T2-FLAIR），上述数据均由多家机构采用不同扫描协议与成像设备采集得到。此外，数据集还以二分类标签的形式提供了患者的MGMT启动子甲基化状态数据。

值得注意的是，MGMT是一种DNA修复酶，新诊断的胶质母细胞瘤患者中，其启动子甲基化状态已被证实为良好的预后因子，同时也是化疗响应的预测指标。本数据集专为肿瘤分割以及MGMT启动子甲基化状态预测的计算图像分析任务而构建。

搜集汇总

背景与挑战

背景概述

RSNA-ASNR-MICCAI-BraTS-2021是一个脑胶质瘤MRI数据集，包含2,040名患者的4种结构模态扫描（T1、T1c、T2、T2-FLAIR）和肿瘤亚区域手动标注真值，以及MGMT启动子甲基化状态标签。数据来自多个机构，具有异质性图像质量，适用于计算图像分析任务，如肿瘤分割和MGMT状态预测。