Expression data from murine MPS I fibroblasts under flavonoids treatment

Flavonoids are biological compounds with high potency to modulate molecular processes. The study was designed to estimate genistein, kaempferoland their mixture impact on global gene expression, with special focus on key processes in MPS pathogenesis. We used microarrays to detail the global program of gene expression underlying flavonoid treatment and identified distinct classes of regulated genes during this process. Murine MPS I fibroblasts were cultivated for 24 hours with 60 and 120 µM genistein, 60 and 120 µM kaempferol and 60 and 120 µM genistein and kaempferol 1:1 mixture.