Stable Tricyclic Antitubercular Ozonides Derived from Artemisinin
收藏Figshare2016-02-12 更新2026-04-29 收录
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https://figshare.com/articles/dataset/Stable_Tricyclic_Antitubercular_Ozonides_Derived_from_Artemisinin/2120941
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New, highly stable tricyclic antitubercular ozonides 9 and 10 derived from artemisinin are reported in 39 and 9% yields, respectively. The ozonide groups of 9 and 10 were found to be stable under strong basic and acidic conditions. The absolute configuration of ozonides 9 was confirmed by X-ray crystallography. Ozonide 10 shows promising antitubercular activity against M. tuberculosis H37Ra and M. tuberculosis H37Rv with MIC values of 0.39 and 3.12 μg/mL, respectively.
创建时间：
2016-02-12
