Three inhibitors of type 1 human immunodeficiency virus long terminal repeat-directed gene expression and virus replication.
收藏PubMed Central1993-03-01 更新2026-05-16 收录
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https://pmc.ncbi.nlm.nih.gov/articles/PMC45975/
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资源简介：
Transcription of type 1 human immunodeficiency virus (HIV-1) provirus is governed by the viral long terminal repeat (LTR). Drugs can block HIV-1 replication by inhibiting activity of its LTR. We report that topotecan, beta-lapachone, and curcumin are potent and selective inhibitors of HIV-1 LTR-directed gene expression, at concentrations that have minor effects on cells. At these concentrations, each drug inhibited p24 antigen production in cells either acutely or chronically infected with HIV-1. Their target is transcriptional function of the LTR. IMAGES:
提供机构：
National Academy of Sciences
创建时间：
1993-03-01
