Bis(imidazolidine)pyridine-NiCl<sub>2</sub> Catalyst for Nitro-Mannich Reaction of Isatin-Derived <i>N</i>‑Boc Ketimines: Asymmetric Synthesis of Chiral 3‑Substituted 3‑Amino-2-oxindoles
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An (S,S)-diphenyldiamine-derived bis(imidazolidine)pyridine (PyBidine)-NiCl2 complex catalyzed the nitro-Mannich reaction of isatin-derived N-Boc ketimines to construct a chiral quaternary aminocarbon center at the C3 position of oxindoles in yields of up to 99% with 95% ee.
创建时间：
2014-05-16
