A randomized controlled trial of oral Azithromycin for the prevention of perinatal infections in pregnant women undergoing labor induction

Objectives: To evaluate oral Azithromycin's effectiveness in reducing intrapartum and puerperal infectionrates in term pregnant women undergoing labor induction and guide antibiotic prophylaxis.Methods: This single-center randomized controlled trialenrolled 472 women with term singleton pregnancies undergoing labor induction, who were randomly assigned to 2 g oral Azithromycin (n=236) or no treatment(n=236). The primary outcome was the overall perinatal infection rate(encompassing intrapartum and/or puerperal infections). Secondary outcomes included maternal and neonatal complications, delivery mode, and safety parameters. Results analysis adopted an intention-to-treat approach.