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A novel P300 inhibitor reverses DUX4-mediated global histone H3 hyperacetylation, target gene expression and cell death

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NIAID Data Ecosystem2026-03-11 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE130522
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资源简介:
DUX4-induced gene expression was compared in the presence vs. absence of the p300 inhibitor, iP300w LHCN-M2 immortalilzed human myoblasts carrying rtTA and a dox-inducible DUX4 gene were cultured in the presence of dox and presence or absence of inhibitor. Negative control was the parent line carrying rtTA only but not DUX4. This eliminated any potential dox-specific effect.
创建时间:
2019-09-23
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