Genome wide association study (GWAS) summary statistics, chronic pain broad and narrow in Mount Sinai BioMe

Summary statistics for GWAS performed as part of 'A computational genetic- and transcriptomics-based study nominates drug repurposing candidates for the treatment of chronic pain' Cote et al (preprint DOI https://doi.org/10.1101/2025.03.07.25323591)

readme:

Genome wide association study summary statistics for analyses performed by Cote et al (associated with preprint DOI  https://doi.org/10.1101/2025.03.07.25323591) in Mount Sinai BioMe cohort using PLINK

Phenotypes: chronic pain (narrow), chronic pain (broad)

Filenames 

biome_eur_broadchronicpain_gwas.broad.glm.logistic.hybrid.gzbiome_eur_narrowchronicpain_gwas.narrow.glm.logistic.hybrid.gz

Column names and descriptions#CHROM Chromosome

POSBase pair position

IDVariant ID (CHR:POS:REF:ALT format)

REFReference allele

ALTAlternative allele

PROVISIONAL_REF?Whether reference allele is marked as provisional (see PLINK documentation for more detail)

A1Effect allele

OMITTEDWhether variant omitted from GWAS regression model

A1_FREQA1 allele frequency 

FIRTH?Whether penalized regression model used

TESTType of test / underlying model 

OBS_CTCount of non-missing observations for variant

OROdds ratio (effect size)

LOG(OR)_SEStandard error of log(OR)

Z_STATZ statistic

PP value 

ERRCODEErrors, if any