Results of bioinformatic analysis for PALB2 variants.

The table reports 5′ or 3′ score modifications due to the detected variants in PALB2 (for greater clarity, when the variants didn't change the score, the corresponding tool is not indicated). Proximal cryptic sites are indicated with the corresponding tool, when the variants led to de novo site it is also indicated. N/A = not applicable as the change is synonymous or intronic.†Location indicates exon/intron, SS stands for splice site and distance to the nearest splice site is indicated in base pairs.&cDNA analysis was performed. No additional products in the carrier sample compared to control samples has been identified (data not shown).