Supplemental dataset: Single nucleotide polymorphisms for creation of polygenic score for early childhood caries.

These data are those used to construct a polygenic score for early childhood caries, as originally provided by Haworth et al., and as used in Blostein et al. 2023 (unpublished). <br> For each SNP in the final PGS used in Blostein et al. 2023, this dataset provide the identifier, chromosome, position, weight, and P-value from the base data (available from https://data.bris.ac.uk/datasets/pkqcnil6e9ju2nyreblt3mvwf/summary_statistics/). <br> The base data is a GWAS meta-analysis of 22 European-ancestry cohorts (base data, n=17,666 children) (Haworth et al. 2018). <br> After quality-control, 6,044,259 SNPs overlapped between the base data and COHRA2 (Supplemental Methods). PGSs were calculated at 7 P-value thresholds: 0.001, 0.05, 0.1, 0.2, 0.3, 0.4 and 0.5. We selected the PGS with the best pseudo- R2 measures (Lee et al. 2012) in cross-sectional models regressing prevalent ECC against each PGS, child sex, and the first 5 genetic ancestry PCs. This was the PGS with P-value&lt;0.001 used as cut off.