Genomic analysis of mouse CD4 T cell anergy using combined ATAC-seq and RNA-seq

T cells that encounter self-antigens after exiting the thymus avert autoimmunity through peripheral tolerance. Pathways for this tolerance include an unresponsive state known as anergy, clonal deletion, and Foxp3+ T regulatory (Treg) cell induction. The transcription factor cues that guide distinct peripheral tolerance outcomes remain unclear. In this study, we took an unbiased molecular approach to identify key transcription factors that underlie T cell anergy induction and maintenance.