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Synergistic and common effects of insulin and IGF-1 receptors on healthy murine ageing

NIAID Data Ecosystem2026-05-02 收录

神经衰老机制

IGF-1信号通路

数据链接：

https://www.ncbi.nlm.nih.gov/sra/ERP152733 数据链接链接失效反馈

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资源简介：

Brain transcriptome of mice aged 3 or 18 months old. The brain (including cerebellum and brain stem) was harvested and hemisected longitudinally.

应用场景：

创建时间：

2025-08-02

神经氧化应激

IGF-1信号通路

Fig1a) Neuron viability measured as percentage of GFP positive cells cultured ± astrocytes after treatment with H2O2. N: neurons, NA: neurons + astrocytes. Names for each file refer to the related fig

NIAID Data Ecosystem100

IGF1 pathway (v2.0)

IGF-1信号通路

分子互作网络

This is the updated version of an original NCI Pathway Interaction Database (PID) network. The list of entities (genes, proteins, chemicals, etc) from the original network was used to query the INDRA

NIAID Data Ecosystem30

Table_1_Transcriptomic Regulation of Muscle Mitochondria and Calcium Signaling by Insulin/IGF-1 Receptors Depends on FoxO Transcription Factors.XLSX

代谢分子机制

IGF-1信号通路

Insulin and IGF-1, acting through the insulin receptor (IR) and IGF-1 receptor (IGF1R), maintain muscle mass and mitochondrial function, at least part of which occurs via their action to regulate gene

NIAID Data Ecosystem20

IGF-1, IGF-1receptor mRNA, and L-[U-14C]-phenylalanine incorporation into proteins, in confluent non-proliferating L6 skeletal muscle cells.

骨骼肌代谢

IGF-1信号通路

Cells were amino acid refed at High AA concentrations (9 mM) with or without presence of inhibitors of molecules in the IGF-1receptor signaling pathway (mean±SE, n = 4-5/group).

NIAID Data Ecosystem30

A multi-omics analysis of chondrocyte allometry

骨与软骨细胞代谢

IGF-1信号通路

Transcriptomic analysis on SHR chondrocytes supported enhanced glycolysis and aberrant mTOR signalling. The insulin-like growth factor (IGF) family is linked with chondrocyte development and homeostas

NIAID Data Ecosystem20

Synergistic and common effects of insulin and IGF-1 receptors on healthy murine ageing

资源简介：

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