Sexually Dimorphic Increases in Bone Mass Following Tissue-specific Overexpression of Runx1 in Osteoclast Precursors
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE216312
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We investigated the skeletal effects of conditional overexpression of Runx1 in preosteoclasts by crossing novel Runx1 gain-of-function mice (Rosa26-LSL-Runx1) with LysM-Cre transgenic mice. The global expression profile duirng osteclast differentiation at day 3 and 5 was compared between Rosa26-Runx1tg/+ cells (control mice) and LysM-Cre;Rosa26-Runx1tg/+ cells (Runx1 gain-of-function) to determine the effects of Runx1 upregulation on osteoclast formation
创建时间：
2023-01-24
