VEGF induces CDC42 activation by unknown mechanism

CDC42 is involved in the formation of filopodia with potential functions in guidance and migration in response to a VEGF gradient. CDC42 is activated downstream of VEGFR2 and involved in the formation of stress fibres by contributing to the activation of the p38 pathway. The activation of CDC42 may rely on FYN activity but the precise mechanism that leads to activation is not known (Lamalice et al. 2004, 2006).

CDC42蛋白参与形成丝足（filopodia），并在响应VEGF梯度时在导向和迁移过程中发挥潜在功能。CDC42在VEGFR2下游被激活，并通过参与p38通路的激活形成应力纤维。CDC42的激活可能依赖于FYN活性，但其激活的确切机制尚不明确（Lamalice等，2004，2006）。