Mitochondrial superoxide dismutase controls metabolic plasticity in pancreatic cancer

Reactive oxygen species have been established to play a critical role in pancreatic carcinogenesis. One of the main antioxidant enzymes is mitochondrial superoxide dismutase (Sod2). Sod2 has been shown to affect tumor initiation and metastatic progression in various cancer types. The impact of Sod2 deletion on pancreatic cancer biology and metabolism has so far not been investigated. We therefore generated three individual Sod2 deficient cell lines from murine pancreatic cancer cell lines isolated from KrasG12D mutant mice and analyzed control and knockout lines with RNA-seq.