uDPMs in AD+CVD - Brain ureido degenerative protein modifications are associated with neuroinflammation and proteinopathy in Alzheimer's disease with cerebrovascular disease

In this study we have profiled the temporal lobe proteome of AD+CVD subjects and age-matched controls. We have studied the occurrence of uDPMs in the particulate and soluble brain proteomes isolated and analyzed by ultracentrifugation-electrostatic repulsion hydrophilic interaction chromatography (UC-ERLIC).