Establish a rapid and efficient chemical reprogramming platform
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2023-08-09
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Establish a rapid and efficient chemical reprogramming platform (RRBS). Establish a rapid and efficient chemical reprogramming platform (RRBS)
Chemically reprogramming somatic cells to iPSCs is time-consuming and low-efficiency. Here, we discribe a rapid chemical reprogramming condition enabling generating iPSCs from MEFs in 12 days. To furt
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Chemical reprogramming of human blood cells into hCiPS cells
Chemical reprogramming offers a fundamentally innovative approach for generating human pluripotent stem (hCiPS) cells using small molecules. Our recent studies showed that this approach was highly eff
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CD3254-RXRa Axis Promotes Chemical Reprogramming via RNA Exosome-Mediated MMVL30 Degradation and Inflammation Suppression [CUT&Tag]
We show that CD-RXRa axis significantly promotes mouse chemical reprogramming of fibroblasts. To identify the molecular mechanisms of CD-RXRa axis in chemical reprogramming, we construct Flag-Rxra-OE
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Tankyrase inhibition facilitates RNA-mediated reprogramming of human somatic cells to naïve pluripotency
In contrast to conventional human pluripotent stem cells (hPSC) that are related to post-implantation embryo stages, naïve hPSC exhibit features of pre-implantation epiblast. Naïve hPSC are establis
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Chemical reprogramming of fibroblasts to photoreceptor like cells [RNA-Seq]. Chemical reprogramming of fibroblasts to photoreceptor like cells [RNA-Seq]
Reprogramming of mouse embryonic fibroblasts (MEFs) to photorereceptor like cells by five chemicals. Overall design: Total RNA from MEFs, reprogramming intermediates (days 5,8) and reprogrammed photor
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