Summary of proton gating parameters of wild–type (wt) and mutant PAC channels tested in this study.

Abbreviations: pH50, half activation pH; nH activation, slope factor of pH–current relationship; BOP, basal opening proportion at neutral pHs as determined by fitting the pH–current relationships; n, number of separate experimental cells; a, p < 0.05; b, p < 0.01; c, p < 0.001; d, p < 0.0001; statistical differences were assessed by one–way ANOVA with post hoc analysis using the Dunnett method (wt–PAC as control). Data are presented as MEAN ± SEM.
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