Supplementary Files

Supplementary Microsoft Excel files containing extended data that is referenced in the text.
These include:File 1: Select proteins’ 30MY
ERC lists, contains multiple-test corrected p-values.

File 2: Pairwise ρ and
unadjusted p-value 30MY ERC matrices for all proteins.

File 3: Enrichment results for
select top ERC protein sets.

File 4: Zip file containing the
mammalian time-scaled phylogeny and maximum likelihood protein trees in newick
format.

File 5: Table depicting the
total number of taxa present for each protein’s sequence data, along with the
number of taxa for which there are paralogy in the uncorrected and 30MY
corrected data.

File 6: Branch time to terminal
branch rate correlation results for the protein set.

File 7: Chi-squared test
results for all proteins testing for whether there is an overrepresentation of
rates below the regression line for short branches (<30MY).

File 8: Branch time vs terminal
branch rate residuals to branch time correlation results for the protein set.

File 9: Wilcoxon matched signed-rank
test significance values testing for branch adjustments following 20MY and 30MY
adjustments.

File 10: Coefficients for the
select proteins used for the linear models containing ACE2 rate rank, Btime
rate rank, and taxonomic orders as independent variables.

File 11: 30MY-adjusted ERC
comparisons within and between CORUM complex members.