Crystal structure of WRN in complex with compound 43
收藏Protein Data Bank Japan2025-07-02 更新2026-04-19 收录
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Crystal structure of WRN in complex with compound 43 Descriptor: (3R,4S)-N-[(2R)-3-cyclohexyl-1-(methylamino)-1-oxopropan-2-yl]-4-{3-[6-(ethanesulfonamido)-2-oxo-2,3-dihydro-1H-1,3-benzimidazol-1-yl]propanamido}-1-[(2-fluoro-4-methylphenyl)acetyl]piperidine-3-carboxamide, Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN, ZINC ION Authors: Pemberton, O.A, Tong, Y, Nocek, B, Tang, H.Y.H. Deposit date: 2025-04-30 Release date: 2025-06-18 Last modified: 2025-07-02 Method: X-RAY DIFFRACTION (1.66 Å) Cite: Validation, Key Pharmacophores, and X-ray Cocrystal Structures of Novel Biochemically and Cellularly Active WRN Inhibitors Derived from a DNA-Encoded Library Screen. J.Med.Chem., 68, 2025
创建时间：
2025-04-30
