pzweuj/EVOScore-2

---
language:
- en
tags:
- biology
- ESM
- language-model
- protein
- VEP
pretty_name: EVOScore-2
size_categories:
- 100M<n<1B
license: mit
---

# Proteome-wide VESM-3B Variant Effect Scores (MIT Clean Mirror)


## ⚠️ Compliance & Mirror Notice

This repository is a **strict subset** of the original [ntranoslab/vesm_scores](https://huggingface.co/datasets/ntranoslab/vesm_scores).

To ensure commercial compliance and safety, all non-commercial components (VESM3, Sequence-only VESM3, and VESM++) have been **permanently removed** from this mirror.

**This repository contains ONLY the `VESM_3B` predictions**, which are based on the ESM2-3B architecture and explicitly released under the MIT License.

---

## Dataset Description

This repository provides precomputed **proteome-wide (UniProtKB, hg19, and hg38) variant-effect prediction scores** using the **VESM_3B** model.

### Included Model
* **VESM_3B:** A protein language model based on **ESM2 (3B parameter)** architecture.

*(Note: The original VESM3 and VESM++ models based on ESM3 have been excluded from this repository).*

For more scientific details, please refer to the original GitHub repo: https://github.com/ntranoslab/vesm

## Files Included
* `hg38_VESM_3B_scores.parquet.gzip`
* `hg19_VESM_3B_scores.parquet.gzip`
* `hg38_VESM_3B_scores.vcf.gz`
* `hg19_VESM_3B_scores.vcf.gz`
* *(And any other Uniprot/metadata files strictly related to VESM_3B)*

## Threshold Recommend

| P_threshold | <-11.6 |
| --------------- | ----------- |
| **B_threshold** | **>-8.5** |

## License <a name="license"></a>

The data provided in this repository is distributed under the **MIT License**.

> **Attribution:**
> This dataset is a mirror of the VESM_3B predictions generated by Ntranos Lab.
> While the original repository contained mixed licenses, the content hosted here is exclusively sourced from the MIT-licensed portion.