Frequency of pfam domains binned by median domain selectivity of active compounds.

Each row represents a set of Pfam domains whose active compounds (against targets with that domain) have a median domain selectivity in the range specified. Domain selectivity is the same as introduced in the “Target Selectivity Distribution” section above, where active targets sharing a common domain are counted only once. The ranges are ordered from top to bottom by increasing number of distinct domain active targets. We report bin counts separately for FDA Approved and Non-FDA compounds.