Cancer Dependency Map, CRISPR Avana dataset 18Q2 (Avana_public_18Q2)

Avana_public_18Q2 contains the results of screening 436 cancer cell lines with the Avana CRISPR-Cas9 genome-scale knockout library generated as part of the Broad Institute's Cancer Dependency Map project.As our screening efforts continue, we will be releasing additional cancer dependency data on a quarterly basis for unrestricted use. For the latest datasets available, further analyses, and to subscribe to our mailing list visit https://depmap.org.Descriptions of the experimental methods and the CERES algorithm are published in http://dx.doi.org/10.1038/ng.3984. Some cell lines were processed using copy number data based on the Sanger Institute whole exome sequencing data (COSMIC: http://cancer.sanger.ac.uk/cell_lines, EGA accession number: EGAD00001001039) reprocessed using CCLE pipelines. Avana_public_18Q2 includes the results of 46 lines not previously made public, while the previously published line HS294T has been dropped for fingerprinting failure.