GWAS for IgA Nephropathy

IgA nephropathy (IgAN) is a common form of immune-mediated glomerulonephritis characterized by glomerular deposition of IgA-containing immune complexes and manifesting with hematuria, proteinuria, and often kidney failure. This dataset is from a genome-wide association study (GWAS) designed to identify novel genetic risk loci for IgAN. In this dataset, seven cohorts were genotyped by Illumina Multi-Ethnic Global Array, consisting of 3,337 IgAN cases and 2,177 healthy controls of European and East Asian ancestries. Three of the provided cohorts were genotyped by Illumina HumanImmuno Chip, which are composed of 2007 cases of IgAN of European ancestry. These cohorts were used in the GWAS meta-analysis, as described in the manuscript entitled "GWAS defines pathogenic signaling pathways and prioritizes drug targets for IgA nephropathy" (Nature Genetics 2022, in press).]]>
All cases used in this study were defined by a kidney biopsy diagnosis of IgAN and any suspected secondary cases due to drugs, malignancy, infection, or autoimmune disease were excluded. All controls used for discovery involved healthy population controls and any individuals with a known diagnosis of kidney disease were excluded. ]]>
2012 - dbGaP data release: Participants of Chinese Han Ancestry 2015 - dbGaP data release: Participants of European Ancestry2022 - dbGaP data release: Participants of European and East Asian Ancestry]]>