BIOGRID CURATED DATA FOR MPE1 (Saccharomyces cerevisiae (S288c))

Protein-Protein, Genetic, and Chemical Interactions for MPE1 (Saccharomyces cerevisiae (S288c)) curated by BioGRID (https://thebiogrid.org); DEFINITION: Essential conserved subunit of CPF cleavage and polyadenylation factor; plays a role in 3' end formation of mRNA via the specific cleavage and polyadenylation of pre-mRNA; contains a ubiquitin-like (UBL) domain, a RNA-binding zinc knuckle motif and a RING finger domain; both the zinc knuckle and RING finger are required for pre-mRNA binding; possible role in ubiquitination of Pap1p; relocalizes to the cytosol in response to hypoxia

蛋白质-蛋白质、遗传和化学相互作用数据集，针对MPE1（酿酒酵母S288c）由BioGRID（https://thebiogrid.org）整理；定义：CPF切割与多聚腺苷酸化因子的保守必要亚基；在mRNA 3'端形成中发挥重要作用，通过特异性切割和polyadenylation的前体mRNA；含有泛素样（UBL）结构域、RNA结合锌指基序和RING finger结构域；锌指和RING finger对于前体mRNA的结合均为必需；可能在Pap1p泛素化中发挥作用；在缺氧条件下重新定位至细胞质。