Targeted deletion of mouse Slc25a28 (Mitoferrin2) reveals Mitoferrin1 and Mitoferrin2 are necessary for liver regeneration and cell proliferation

Hepatocyte-specific loss of Slc25a37 (Mitoferrin1) in Mitoferrin2-/- mice did not affect animal viability or liver size suggesting that there must be alternative hepatocyte mitochondrial iron importers that function in the absence of Mitoferrins. Liver mRNA profiles from aged-matched controls and hepatocyte-specific loss of both mitoferrins (Alb-cre Mfnr1-/- Mfrn2-/-) animals.在线粒体铁转运蛋白2（Mitoferrin2）基因敲除小鼠中，肝细胞特异性敲除Slc25a37（线粒体铁转运蛋白1，Mitoferrin1）并未影响小鼠存活率与肝脏体积，这表明在缺失线粒体铁转运蛋白的情况下，存在其他可发挥功能的肝细胞线粒体铁转运蛋白。本数据集包含年龄匹配的对照组小鼠，以及肝细胞特异性双敲除两类线粒体铁转运蛋白（Alb-cre Mfnr1-/- Mfrn2-/-）的小鼠肝脏mRNA表达谱。