Baseline characteristics and follow-up in study populationa.

ALT, alanine aminotransferase; BCP, basal core promoter; ENH, HBeAg negative hepatitis; HBeAg, hepatitis B e antigen; HBV, hepatitis B virus; HCC, hepatocellular carcinoma; IT, immune-tolerant; IC, immune-clearance; LR, non/low-replicative.aTotal number of subjects may vary because of missing value due to PCR/sequencing failure or nonparticipation in follow-up examination.b31 subjects with missing data on baseline ALT levels or HBeAg status were excluded from analysis of natural history.cP2 test (categorical variable).d11 subjects had unclassified subgenotypes.