Comparison of toxicological effects and exposure levels between triclosan and its structurally similar chemicals using in vitro tests for read-across case study

To improve prediction accuracy of read-across, we compared biological similarities between triclosan and its structurally similar chemicals including diclosan and 1-chloro-3-(4-chlorophenoxy) benzene. To elucidate and compare the potential mechanisms between them, we performed in vitro toxicogenomics with rat primary hepatocytes.为提升交叉参照（read-across）方法的预测精度，本研究对比了三氯生（triclosan）与其结构类似物（包括二氯生（diclosan）和1-氯-3-(4-氯苯氧基)苯（1-chloro-3-(4-chlorophenoxy) benzene））之间的生物学相似性。为阐明并对比这些化合物间的潜在作用机制，我们采用大鼠原代肝细胞开展了体外毒理基因组学（in vitro toxicogenomics）实验。