Determination of The Factors Affecting The Latent Period of Periviable Premature Rupture of Membranes Cases and Evaluation of Newborn Outcomes

Premature rupture of membranes is the loss of amniotic fluid due to damage to the chorioamniotic membranes surrounding the fetus before labor. Preterm premature rupture of membranes (PPROM, PPROM) is defined as the rupture of membranes before the 37th week of pregnancy and is seen in 3 percent of all pregnancies. It occurs in approximately 0.5 percent (%) of pregnancies <27 weeks, 1 percent (%) of pregnancies between 27 and 34 weeks, and 1 percent (%) of pregnancies between 34 and 37 weeks [1], [2] .
Although the etiopathogenesis of preterm PROM has not been clearly defined, there are different mechanisms that may be related. The integrity of fetal membranes is due to extracellular membrane proteins, including collagens, fibronectin, and laminin. Matrix metalloproteases (MMPs) reduce membrane strength by causing increased collagen degradation [3]. Tissue inhibitors of MMPs (TIMMPs) bind to MMPs and inhibit MMP-associated proteolysis, thus helping to maintain membrane integrity [4]. It has been shown that intraamniotic infection, especially in early pregnancy, may be associated with PPROM.

羊膜过早破裂是指由于胎儿周围的绒毛膜-羊膜在分娩前受损而导致的羊水流失。早产性羊膜过早破裂（PPROM，PPROM）是指在妊娠第37周之前发生的羊膜破裂，在所有妊娠中占3%。它发生在约0.5%（%）的妊娠小于27周、1%（%）的妊娠在27至34周之间，以及1%（%）的妊娠在34至37周之间[1]，[2]。尽管早产性PROM的病因病理机制尚未明确界定，但存在多种可能与该现象相关的机制。胎儿膜的结构完整性依赖于细胞外膜蛋白，包括胶原蛋白、纤连蛋白和层粘连蛋白。基质金属蛋白酶（MMPs）通过引起胶原蛋白降解增加来降低膜强度[3]。组织金属蛋白酶抑制剂（TIMMPs）与MMPs结合并抑制与MMP相关的蛋白酶解，从而有助于维持膜完整性[4]。研究表明，羊膜腔内感染，尤其是在早期妊娠，可能与PPROM相关。