Dataset for: The effects of an alpha-2-adrenoceptor agonist, antagonist, and their combination on the blood insulin, glucose, and glucagon concentrations in insulin sensitive and dysregulated horses

These are the raw data, sedation scoring matrix, and statistical analyses of a prospective, randomized, crossover, drug study. Each horse received 4 treatments with a minimum 13 day washout period. Our hypothesis was that the use of vatinoxan (a peripherally acting alpha2 antagonist) would reduce or prevent the insulin and glucose fluctuations induced by the alpha2 agonist, detomidine.

本数据集包含了前瞻性、随机交叉药物研究的原始数据、镇静评分矩阵及统计分析。每匹马均接受了四种治疗方案，且每种方案之间设有至少13天的清洗期。本研究假设，使用外周作用的α2受体拮抗剂瓦替诺克斯（Vatinoxan），可以减少或预防由α2激动剂盐酸右美托咪定（Detomidine）引起的胰岛素和血糖波动。