Results of branch-site tests for selection on vWF.

Parameter estimates for branch-site tests (H0: 2 = 1; HA: 2>1) applied to vWF sequences with either the clade Didelphini ( = −5436.01; = −5422.79) or Didelphini excluding Chironectes ( = −5440.51; = −5431.74; parameter values in parentheses) designated as foreground lineages.1Site classes 0 and 1 comprise sites under purifying selection (001 = 1), respectively in both foreground and background lineages. Site class 2 allows a proportion of positively selected sites in the foreground lineages, where 2a includes sites under purifying selection (002>1).