Oxidative Addition Complexes as Precatalysts for Cross-Coupling Reactions Requiring Extremely Bulky Biarylphosphine Ligands

In this report, we
describe the application of palladium-based
oxidative addition complexes (OACs) as effective precatalysts for
C–N, C–O, and C–F cross-coupling reactions with
a variety of (hetero)­arenes. These complexes offer a convenient alternative
to previously developed classes of precatalysts, particularly in the
case of the bulkiest biarylphosphine ligands, for which palladacycle-based
precatalysts do not readily form. The precatalysts described herein
are easily prepared and stable to long-term storage under air.