SARS-CoV-2 infects the brain vasculature in COVID-19 patients and a hiPSC-derived model of the blood-brain barrier

We report the transcriptional changes of an hipsc-derived model of the blood-brain barrier to infection with SARS-CoV-2. Furthermore, the neurovascular niche was isolated from human brain biopsies to compare the transcriptional signatures of hipsc-derived endothelial cells and human neurovascular niche. Overall design: hipsc-derived endothelial cells were either mock infected of exposed to SARS-CoV-2.