Cryo-EM structure of siponimod -bound Sphingosine-1-phosphate receptor 1 in complex with Gi protein
收藏Protein Data Bank Japan2025-07-02 更新2026-03-21 收录
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Cryo-EM structure of siponimod -bound Sphingosine-1-phosphate receptor 1 in complex with Gi protein Descriptor: 1-[[4-[(~{E})-~{N}-[[4-cyclohexyl-3-(trifluoromethyl)phenyl]methoxy]-~{C}-methyl-carbonimidoyl]-2-ethyl-phenyl]methyl]azetidine-3-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... Authors: Jia, G.W, Yuan, Y, Su, Z.M, Shao, Z.H. Deposit date: 2021-05-24 Release date: 2021-09-29 Last modified: 2025-07-02 Method: ELECTRON MICROSCOPY (2.98 Å) Cite: Structures of signaling complexes of lipid receptors S1PR1 and S1PR5 reveal mechanisms of activation and drug recognition. Cell Res., 31, 2021
创建时间:
2021-05-24



