MOESM2 of Impact of aromatase inhibitor treatment on global gene expression and its association with antiproliferative response in ER+ breast cancer in postmenopausal patients

Additional file 2. Table S1. Published gene-signatures. Table S2. Study endpoints. Table S3. Study demographics. Table S4. List of patients and their status of HER2, Ki67 and CCCA. Table S5. Ki67 data summary. (A) Percentage change in Ki67 expression after 2-weeks AI-treatment. (B) Anti-proliferative response summary. (C) Summary of number of tumours that reached CCCA. Table S6. Genes whose baseline expression significantly correlated with Change.Ki67 (p < 0.005) in HER2- group. Table S7. Unpaired t-test of significance for the difference between two-group means: i) non-responders vs responders; ii) noCCCAs vs CCCAs in HER2- group. Table S8. Genes whose baseline expression significantly correlated with residual Ki67 (p < 0.005) in HER2- group. Table S9. Pathway analysis of genes in Table S8. Table S10. Genes whose baseline expression is significantly different (p < 0.001) between CCCA and noCCCA in HER2- group. Table S11. Genes significantly regulated by AI with p < 0.005 by univariate Two-sample T-test in HER2- group. Table S12. Top 20 AI-downregulated / AI-upregulated genes, and additional AI-regulated genes of interest identified from HER2- paired tumours. Genes were ranked by fold-change (FC). The Significantly different (p-value) derived from Mann-Whitney test comparing the relative change in expression of a given gene in the HER2- group versus the HER2+ group. ns: p >= 0.05. Table S13. Enriched canonical pathways of the significantly AI-regulated genes in Table S11. Table S14. Correlations of the change in ESR1 / gene-signatures and change in Ki67 / residual-Ki67 in i) HER2- group, ii) HER2+ group, iii) Significance of the difference between the 2 correlation-coefficients. Table S15. Genes significantly regulated by AI with p < 0.005 by univariate Two-sample T-test in HER2+ group. Table S16. Genes whose baseline expression significantly correlated with Change.Ki67 (p < 0.005) in HER2+ group. Table S17. Genes whose baseline expression significantly correlated with residual-Ki67 (p < 0.005) in HER2+ group.