Investigating the Gut Microbiome in Central Disorders of Hypersomnolence

Microbiota affects the central nervous system by modulation of neuronal pathways, through the neuroendocrine and immune system, hypothalamus-pituitary-adrenal axis, and various metabolic pathways. Microbiota can also influence the circadian rhythms of the host. The gut microbiota affects sleep mostly through the production of neurotransmitters and short-chain fatty acids. In this study, we observed the gut microbiota composition of patients suffering from narcolepsy type 1, narcolepsy type 2, and idiopathic hypersomnia.