Phased genome assemblies in the critically endangered Chinese Bahaba (Teleostei, Sciaenidae)

The fitness of organisms is influenced by the number of deleterious mutations in the genome. Although the distribution pattern of haplotype-specific genetic load plays an important role in shaping the evolutionary trajectory of natural and captive populations, it has been so far elusive in diploids due to mixing of haplotypes during assembly and genotyping. Herein we produce two phased genome assemblies from female and male individuals of the critically endangered fish Chinese Bahaba (Bahaba taipingensis, Sciaenidae, Teleostei). Simulations suggest that purifying selection has limited power to remove genetic load in captive breeding, calling for genotyping interventions in conservation programs, and that higher inter-haplotypic variance of genetic load predicts more efficient load removal by artificial selection.

搜集汇总

背景与挑战

背景概述

该数据集提供了濒危鱼类中国黄唇鱼（Bahaba taipingensis）的雌性和雄性个体分相基因组组装，用于分析单倍型特异性遗传负荷的分布模式。研究揭示了纯化选择在人工繁殖中去除遗传负荷的局限性，强调了遗传干预在保护计划中的必要性，并指出单倍型间遗传负荷方差越高，人工选择去除负荷的效率越高。