Blocking the activation of TGFβ signaling in liver sinusoidal endothelial cells alleviates liver fibrosis in mice. Blocking the activation of TGFβ signaling in liver sinusoidal endothelial cells alleviates liver fibrosis in mice
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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA996947
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Purpose: To detect the alterations in transcriptional profile of primary LSECs isolated from Tgfbr2 ECKO mice and Tgfbr2f/f mice in CCl4-induced liver fibrosis. Overall design: Comparative gene expression profiling analysis of RNA-seq data for LSECs from Tgfbr2 ECKO mice and Tgfbr2f/f mice treated with CCl4. Methods: we generated endothelial-specific Tgfbr2 knockout mice. We then subjected Tgfbr2 ECKO and its littermates Tgfbr2f/f mice to CCl4 injection for 6 weeks.
创建时间：
2023-07-20
