Gut microbiome with RAS mutation and chemotherapy response in patients with advanced or metastatic colorectal cancer: a pilot, exploratory study

Gut microbiomes play a pivotal role in tumor microenvironment interactions, inflammation modulation, and immune regulation, impacting anticancer therapy response. This pilot study investigated the gut composition according to clinical characteristics and its association with chemotherapy response in patients with metastatic colorectal cancer (mCRC).