Expression of ID4 in the nephric duct

The Inhibitor of DNA-binding 4 (ID4) gene is expressed in the developing nephric duct (inferred from the mouse homolog). In mouse embryos, Pax2 and Gata3 activate expression of Id4 but it is unknown if the regulation is due to direct binding of the factors to the Id4 gene (Boualia et al. 2013). ID4 appears to be involved in regulating stem cell survival and differentiation (reviewed in Patel et al. 2015).

DNA结合抑制因子4（ID4）基因在肾脏导管发育过程中表达（据小鼠同源基因推断）。在胚胎小鼠中，Pax2和Gata3激活Id4的表达，但该调控是否由于这些因子直接结合至Id4基因尚不清楚（参见Boualia等人的研究，2013年）。ID4似乎在调节干细胞的存活和分化过程中发挥作用（Patel等人综述，2015年）。