RNA Sequencing profiling of Th17 cells treated with CKBA or DMSO

NIAID Data Ecosystem2026-05-10 收录

Th17细胞调控

RNA测序药物机制

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https://www.ncbi.nlm.nih.gov/sra/SRP667528 数据链接链接失效反馈

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Derivatives of boswellic acid show promise for treating autoimmune diseases. We identify CKBA as a potent inhibitor of T helper 17 (Th17) cell differentiation,and try to understand how CKBA inhibit the differentiation of Th17 cells by RNA sequencing.

创建时间：

2026-01-29

Reconstruction of the dynamic regulatory network that controls Th17 cell differentiation by systematic perturbation in primary cells (Affymetrix timecourse IL23 KO)

Th17细胞调控

免疫转录组

Despite their enormous importance, the molecular circuits that control the differentiation of Th17 cells remain largely unknown. Recent studies have reconstructed regulatory networks in mammalian cell

NIAID Data Ecosystem100

Genomewide mapping of Trim33 binding in Th17 cells

转录因子结合位点

Th17细胞调控

We report the genome-wide binding of Trim33 in Th17 cells. We found that more than 90% of Trim33 binding regions was located in non-conding sequence, and therefore reflect the role of Trim33 as a tra

NIAID Data Ecosystem60

Quantitative RNAseq Analysis of Treatment Outcomes with Talazoparib, Romidepsin or Combination in MBL2 cell line. Quantitative RNAseq Analysis of Treatment Outcomes with Talazoparib, Romidepsin or Combination in MBL2 cell line

RNA测序药物机制

癌症治疗靶点验证

To explore the molecular mechanisms by which romidepsin potentiates the effect of talazoparib, RNA sequencing analysis of MBL2 cell lines treated with talazoparib, romidepsin, or talazoparib plus romi

NIAID Data Ecosystem30

Table_2_Interleukin 27 is a novel cytokine with anti-inflammatory effects against spondyloarthritis through the suppression of Th17 responses.xlsx

脊柱关节炎免疫治疗

Th17细胞调控

IntroductionSpondylarthritis (SpA) development in HLA-B27/human β2-microglobulin transgenic rat (B27-rat) is correlated with altered conventional dendritic cell (cDC) function that promotes an inflamm

NIAID Data Ecosystem70

Transcription factor TCF1 binds Rorgt and orchestrates a regulatory network that determines homeostatic Th17 cell state [ATAC-seq]. Transcription factor TCF1 binds Rorgt and orchestrates a regulatory network that determines homeostatic Th17 cell state [ATAC-seq]

Th17细胞调控

染色质可及性分析

CD4+ T helper 17 (Th17) cells encompass a spectrum of cell states including homeostatic cells that maintain physiological functions such as barrier integrity and pathogenic cells that drive autoimmune

NIAID Data Ecosystem40

RNA Sequencing profiling of Th17 cells treated with CKBA or DMSO

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