Identification of products resulting from the hydrolysis of Aß1–40 by NEP.

NEP mediated hydrolysis was carried out as described in Table 2. The reaction was stopped by adding 10 µL of 5% TFA when approximately half of the substrate had been hydrolyzed (360 min.). The acidified reaction mixture was subjected to HPLC analysis as described in Table 4. Each peak was isolated and subjected to mass spectral analysis.