Chikungunya masquerading as dengue infection in Sri Lanka uncovered by metagenomics

Dengue is a significant threat to human health in South and Southeast Asia where during outbreaks patients are treated without diagnostic confirmation. This approach though cost-effective may miss important infections especially those caused by other arboviruses (e.g., Zika, Chikungunya and West Nile virus). This study aimed to diagnose missed infections mimicking dengue by using metagenomic next generation sequencing (mNGS).