Information on drug validation experiments.

Tab information: "Primary hits" lists all drugs that reached at least 1.5 or -1.5 from the drug repurposing screen. "Rescuing drugs" lists all drugs that improved the DPAGT1 model (whether directly or derived from the screen). This includes the quantitative results of what % they improved eye size over vehicle-treated DPAGT1 model flies and their p-value (see Methods for statistics). The low/medium/high doses can be found in the tab "Compound sources, vehicles". "Non-rescuing drugs" lists drugs that worsened the model or had no effect. "Categories of tested drugs" lists the general drug class that each tested drug falls into. " Compound sources, vehicles" lists each drug tested during validation, where they were sourced from (including product numbers), their vehicle used, and doses used for each drug. Cells are labeled blue to indicate statistically significant positive changes, red represents negative changes, and gray represents non-significant changes. (XLSX)