Supplemental Datasets for "SPIDR enables multiplexed mapping of RNA-protein interactions and uncovers a mechanism for selective translational suppression upon cell stress"

Below is a brief description of each supplementary dataset. For more details, please see the Materials and Methods section of the manuscript here: https://doi.org/10.1101/2023.06.05.543769.

Dataset S1: LC-MS/MS based protein quantification of the “Control IP”, 5 distinct “single RBP IPs” and “Pooled IP targeting 10 RBPs” (see STAR Methods for details), related to Figure S2.

Dataset S2: LC-MS/MS based protein quantification of the “HEK293T total lysate” and the supernatants after the “Control IP”, 5 distinct “single RBP IPs” and “Pooled IP targeting 10 RBPs” (see STAR Methods for details), related to Figure S2.

Dataset S3: LC-MS/MS based protein quantification of the “Control IP” and “Pooled IP targeting 39 RBPs” (see STAR Methods for details), related to Figure S1.

Dataset S4: LC-MS/MS based protein quantification of the HEK293T total lysates generated either from “Control (Solvent)”- or “Torin1”-treated cells (see STAR Methods for details), related to Figure 7 and Table S6.

Dataset S5: LC-MS/MS based protein quantification of the 4EBP1 IP from HEK293T lysates generated either from “Control (Solvent)”- or “Torin1”-treated cells (see STAR Methods for details), related to Figure S7.

Dataset S6: LC-MS/MS based protein quantification of the IgG IP and V5 IP from HEK293T lysates (see STAR Methods for details), related to Figure S2.